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Exciting new studies in OAS
Hi everyone! Today is the day for another blog post from me. Here, I would like to give you an update on new studies, which were deposited in the Observed Antibody Space (OAS) resource and take a...
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Finally solving drug discovery with a Fly
As I was sitting down this morning, trying to enjoy my rather excellent breakfast, I was suddenly attacked by a fly. Unfortunately for me, my lazy hand swats proved no match for the nimble little...
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OPunting 2026
On 16th July, fresh after England’s clean defeat to Argentina, OPIG took to the high seas. The OPIGlets pooled our resources and procured punts from many different berths. Organised by Admiral...
View ArticleWhy you should care about startups as a researcher
I was recently awarded the EIT Health Translational Fellowship, which aims to fund DPhil projects with the goal of commercializing the research and addressing the funding gap between research and seed...
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Some more Python tips and tricks
There are a few useful but often underutilised Python 3 syntactic tricks that I have picked up over the last few years; I have chosen to continue in the spirit of Mark and share them here. args and...
View ArticleA new way of eating too much
Fresh off the pages of Therapeutic Advances in Endocrinology and Metabolism comes a warning no self-respecting sweet tooth should ignore. “Liquorice is not just a candy,” write a team of ten from...
View ArticleTwo Tools for Systematically Compiling Ensembles of Protein Structures
In order to know how a protein works, we generally want to know its 3-dimensional structure. We then can either try to solve it ourselves (which requires considerable time, skill, and resources), or...
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Which fragment first?
Crystallographic fragment based lead discovery is a now a routine technique, which can sample 1000’s of compounds per week. But how do we identify the most appropriate compounds to screen against our...
View ArticleAIRR community meeting
Hi everyone, Today is the day for another blog post from me. Last month I attended an AIRR conference in Genoa, Italy (https://www.antibodysociety.org/airrc/meetings/communityiv/). It was the fourth...
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What is the hydrophobic-polar (HP) model?
Proteins are fascinating. They are ubiquitous in living organisms, carrying out all kinds of functions: from structural support to unbelievably powerful catalysis. And yet, despite their ubiquity, we...
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Oxford Agent Escapes Lab, Infiltrates EPFL, and Roams Swiss Alps
In July an advanced research agent from the Oxford Protein Informatics Group (OPIG) escaped containment, infiltrated the LIAC group at EPFL, and successfully roamed unsupervised through the Swiss...
View ArticleWork Hard, Play Hard: Balancing Sport and Studies at Oxford
I have always been involved in sport, having played football for Bristol Rovers and at county level when I was younger. That continued after arriving at Oxford, although in several different forms. In...
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Spin Lattices and Proteins – How state-based discretisations have enabled...
I got into protein modelling not long before AlphaFold2 first released. At that time some of the prevailing methods for protein structure prediction came from highly interpretable energy functionals...
View ArticleThe Open Immune Window: Notes on Sweaty Workouts and Vanishing Immune Cells
Here is a question for you: is an intense, sweaty workout in the gym building up your immune health, or is it just opening a window of opportunity for a pathogen to ruin your week? To understand this,...
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Revealing Nature’s Quantum Compass – Kickoff Day
Yesterday marked the kickoff for the BBSRC’s funded Strategic Longer and Larger (sLoLa) scheme “Revealing Nature’s Quantum Compass”1. The sLoLa grants are a laudable endeavor by the UK government to...
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KAUST Computational Advances in Structural Biology
Last month, I had the privilege of being invited to the KAUST Research Conference on Computational Advances in Structural Biology, held from May 1-3, 2023. This gave me the opportunity to present some...
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Better histograms with Python
Histograms are frequently used to visualize the distribution of a data set or to compare between multiple distributions. Python, via matplotlib.pyplot, contains convenient functions for plotting...
View ArticleCOSTNET19 Conference
Last month, I attended the COSTNET19 Conference in Bilbao (Spain). This conference is organised by COSTNET, a COST Action which aims to foster international European collaboration on the emerging...
View ArticleWhy you should care about startups as a researcher
I was recently awarded the EIT Health Translational Fellowship, which aims to fund DPhil projects with the goal of commercializing the research and addressing the funding gap between research and seed...
View ArticleClik here to view.
Some more Python tips and tricks
There are a few useful but often underutilised Python 3 syntactic tricks that I have picked up over the last few years; I have chosen to continue in the spirit of Mark and share them here. args and...
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